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  2. Phillip Dettleff F.

Phillip Dettleff F.

Phillip Dettleff F.
Cargo

Director de Pregrado / Profesor Asistente

Contacto
email phillip.dettleff@uc.cl
  • Médico Veterinario, Universidad de Chile.
  • Doctor en Ciencias Agropecuarias y Veterinarias. Universidad de Chile.
  • Genética y Evolución (VET1120).
  • Técnicas Moleculares aplicadas en Ciencias animales (VET111D).
  • Biología y Enfermedades de Peces (VET132P).
  • Internado Electivo en Pequeños Animales (VET288A)
  • Producción Acuícola-Salmones (AGZ358).
  • Efectos de estresores ambientales en especies acuicolas.
  • Genética poblacional en especies marinas.
  • Genómica aplicada a producción animal.
  • Interacción molecular hospedéro-patógeno y su efecto en resistencia genética a enfermedades en animales.
  • 2025-2029: Proyecto FONDECYT Regular 1251250: Insights into Canine Oocyte Development: Deciphering Signaling Dynamics via Gap Junction-Connexin Connection. Co-investigador. Universidad de Chile.
  • 2024-2026: Proyecto Plazas Postdoctorales UC 2024: Acuicultura Sustentable. Investigador Patrocinante. Pontificia Universidad Católica de Chile.
  • 2024-2025: Proyecto Piloto de Investigación Interdisciplinaria RCER 2023: Búsqueda de nuevos aditivos para alimentos con propiedades inmunoreguladoras para salmones en las especies vegetales de la Región de Magallanes calafate (Berberis microphylla) y luga Roja (Sarcopeltis skottsbergii). Co-investigador.
  • 2023-2026: Proyecto FONDECYT Inicio 11230153: Understanding the effect of microplastic in native marine fish using genomics resources: effect on intestinal microbiota, stress response and immune system in Genypterus species. Investigador responsable.
  • 2023-2027: Proyecto FONDECYT Regular 1231082: Emergent multidrug-resistant Salmonella infantis in food animals: understanding dissemination, reservoirs, and genomic features facilitating its emergence. Co-investigador.
  • 2021-2024: Proyecto FONDECYT Regular 1211285: Understanding the regulation of canine oocyte development: role of micro RNA. Co-investigador.
  • 2020-2021: Proyecto Interno de investigación, creación e innovación tecnológica: Identificación molecular de parásitos anisákidos extraídos de merluzas destinadas a consumo humano obtenidas en la costa cercana a la ciudad de Talca. Investigador Alterno. UST.
  • 2018-2021: Proyecto FONDECYT de Postdoctorado 3180283: Identificación y validación de nuevos biomarcadores de estrés térmico en Congrio colorado (Genypterus chilensis) por medio de transcriptómica, un modelo para la diversificación acuícola en Chile. Investigador Responsable. UNAB.
  • 2025: Becerra, S., Arriagada-Solimano, M., Escobar-Aguirre, S., Palomino, J., Aedo, J., Estrada, J.M., Barra-Valdebenito, V., Zuloaga, R., Valdes, J.A., Dettleff, P. High temperature induces oxidative damage, immune modulation, and atrophy in the gills and skeletal muscle of the teleost fish black cusk-eel (Genypterus maculatus). Developmental and Comparative Immunology, 164(2025):105332.
  • 2025: García-Huidobro, M.R., Zuloaga, R., Llanos-Azócar, K., Dettleff, P., Aldana, M., Urzúa, Á., Duarte, C., Molina, A., Varas, O., Pulgar, V.M., Valdés, J.A., Pulgar, J. Upwelling effects across different levels of biological organization: Integrating biochemical constituents, physiological performance and muscle transcriptomic response in the intertidal fish Girella laevifrons (kyphosidae). Marine Environmental Research, 205(2025): 107023.
  • 2025: Dettleff P, Palomino J, González-Coppia F, De Los Reyes M. Transcriptomic profiling of miRNA-mRNA interactions in canine oocytes and cumulus cells during in vitro maturation: a sequencing analysis. Theriogenology, 242:117454.
  • 2025: Dettleff P, Fuentes M, Gonzalez P, Aedo J, Zuloaga R, Estrada JM, Molina A, Valdes JA. Generating transcriptomic resources in the teleost fish black cusk-eel (Genypterus maculatus) to evaluate thermal stress in the liver under a climate change scenario. Fish Physiol Biochem, 51(2):75.
  • 2024: Dettleff, P., Yehwa, J., Peñaloza, C., Pulgar, R., Sáez, A., Robledo, D., Escobar-Aguirre, S. Effect of CRISPR/Cas9 Targets Associated with Iron Metabolism and Its Variation on Transcriptional Regulation of SHK-1 Cell Line as a Model for Iron Metabolism. Fishes, 9(6): 198.
  • 2024: Gills de novo assembly reveals oxidative stress, unfolded protein, and immune response on red cusk-eel (Genypterus chilensis) under thermal stress. Marine Environmental Research, 196(2024): 106440. Dettleff, P., Toloza, C., Fuentes, M., Aedo, J., Zuloaga, R., Estrada, J. M., A., Molina, A., Valdés, J.A.
  • 2024: Dynamic Expression of Follicle-Stimulating Hormone and Estrogen mRNA Receptors Associated with microRNAs 34a and -let-7c in Canine Follicles during the Estrous Cycle. Animals, 14(2): 214. De Los Reyes, M., Dettleff, P., Palomino, J., Peralta, O., Vergara, A.
  • 2023: High-Temperature Stress Induces Autophagy in Rainbow Trout Skeletal Muscle. Fishes, 8: 303. Molina, A., Dettleff, P., Valenzuela-Muñoz, V., Gallardo-Escarate, C., Valdés, J.A.
  • 2023: Host-pathogen interaction involving cytoskeleton changes as well as non-coding regulation as primary mechanisms for SRS resistance in Atlantic salmon. Fish & Shellfish Immunology, 136: 108711. Martinez, V., Dettleff, P., Zamorano, P., Galarce, N., Borie, C., Naish, K.
  • 2022: High-Temperature stress effect on the red cusk-eel (Genypterus chilensis) liver: transcriptional modulation and oxidative stress damage. Biology, 11(7): 990. Dettleff, P., Zuloaga, R., Fuentes, M., Gonzalez, P., Aedo, J., Estrada, J. M., A., Molina, A., Valdés, J.A.
  • 2022: Molecular Characterization of Embryos with Different Buoyancy Levels in the Yellowtail Kingfish (Seriola lalandi). Animals, 12(6): 720. Dettleff, P., Rodriguez, J., Patiño-García, D., Orellana, R., Castro, R., Escobar-Aguirre, S., Moreno, R.D. Palomino, J.
  • 2022: RNA-seq analysis reveals the dynamic regulation of proteasomal and autophagic degradation systems of rainbow trout (Oncorhynchus mykiss) skeletal muscle challenged with infectious pancreatic necrosis virus (IPNV). Aquaculture 552 (2022), 738000. Aedo, J., Aravena-Canales, D., Dettleff, P., Fuentes-Valenzuela, M., Zuloaga, R., Rivas-Aravena, A., Molina, A., Valdés, J.A.
  • 2022: Estimates of Effective Population Size in Commercial and Hatchery Strains of Coho Salmon (Oncorhynchus kisutch (Walbaum, 1792)). Animals, 12(5):647. Martinez, V., Dettleff, P., Galarce, N., Bravo, C., Dorner, J., Iwamoto, R. N., Naish, K.
  • 2021: RNA-Seq-Based Analysis of Cortisol-Induced Differential Gene Expression Associated with Piscirickettsia salmonis Infection in Rainbow Trout (Oncorhynchus mykiss) Myotubes. Animals 11(8), 2399. Zuloaga, R., Dettleff, P., Bastias-Molina, M., Meneses, C., Altamirano, C., Valdés, J.A., Molina, A.
  • 2021: Transcriptomic analysis reveals a Piscirickettsia salmonis-induced early inflammatory response in rainbow trout skeletal muscle. Comparative Biochemistry and Physiology Part D: Genomics and Proteomics, 100859. Carrizo, V., Valenzuela, C., Aros, C., Dettleff, P., Valenzuela-Muñoz, V., Gallardo-Escarate, C., Altamirano, C., Molina, A., Valdés, J.A.
  • 2021: Survey of Zoonotic Bacterial Pathogens in Native Foxes in Central Chile: First Record of Brucella canis Exposure. Animals, 11(7), 1980. Galarce, N., De la Fuente, S., Escobar, B., Dettleff, P., Abalos, P., Hormazábal, J. C., Flores, R., Sallaberry-Pincheira, N., Martínez, V.
  • 2021: Embryo buoyancy and cell death gene expression during embryogenesis of yellow-tail kingfish Seriola lalandi. Frontiers in Cell and Developmental Biology, 9:630947. Palomino, J., Gómez, C., Otarola, M.T., Dettleff, P., Orellana, R., Patiño-García, D., Moreno, R.D.
  • 2021:  Temperature effect on oxidative stress and egg quality-related genes on post-ovulatory eggs and ovary of red cusk-eel (Genypterus chilensis). Journal of Fish Biology, 98(5):1475-1480. Dettleff, P., Zuloaga, R., Fuentes, M., J., Estrada, J.M., Molina, A., Valdés, J.A.
  • 2021: Genomic features and antimicrobial resistance patterns of Shiga toxin-producing Escherichia coli strains isolated from food in Chile. Zoonoses and Public Health, 68(3):226-238. Sánchez, F., Fuenzalida, V., Ramos, R., Escobar, B., Neira, V., Borie, C., Lapierre, L., López, P., Venegas, L., Dettleff, P., Johnson, T., Fuentes-Castillo, D., Lincopán, N., Galarce, N.
  • 2021: First genome sequence of Chilean Brucella canis SCL strain provides insights of the epidemiology and virulence factors explaining differences between geographical origins. Electronic Journal of Biotechnology, 49: 1-4. Borie, C., Bravo, C., Dettleff, P., Galarce, N., Dorner, J., and Martínez, V.
  • 2020: Physiological and molecular responses to thermal stress in red cusk-eel (Genypterus chilensis) juveniles reveals atrophy and oxidative damage in skeletal muscle. Journal of Thermal Biology, 94: 102750. Dettleff, P., Zuloaga, R., Fuentes, M., González, J., Aedo, J., Estrada, J.M., Molina, A., Valdés, J.A.
  • 2020: Effect of bacterial LPS, poly I:C and temperature on the immune response of coelomocytes in short term cultures of red sea urchin (Loxechinus albus). Fish & Shellfish Immunology, 21:S1050-4648(20)30651-3. Dettleff, P., Villagra, M., González, J., Fuentes, M., Estrada, J.M., Valenzuela, C., Molina, A., Valdés, J.A.
  • 2020: Prevalence and Genomic Characterization of Brucella canis Strains Isolated from Kennels, Household, and Stray Dogs in Chile. Animals, 10 (11): E2073. Galarce, N., Escobar, B., Martínez, E., Alvarado, N., Peralta, G., Dettleff, P., Dorner, J., Martínez, V., Borie, C.
  • 2020: Gene and protein expression of connexins 37 and 43 in cumulus-oocytes-complexes throughout the canine oestrous cycle. Reproduction, Fertility and Development, 32(11):976-987. Palomino, J., Gallegos, C., Espinoza, R., Ramirez, G., Dettleff, P., Peralta, O., Parraguez, V., De los Reyes, M.
  • 2020: Understanding the population structure and reproductive behavior of hatchery-produced yellowtail kingfish (Seriola lalandi). Aquaculture, 522: 734948. Dettleff, P., Hernandez, E., Patridge, G., Lafarga-De la Cruz, F., Martinez, V.
  • 2019: Identification and Evaluation of Long Noncoding RNAs in Response to Handling Stress in Red Cusk-Eel (Genypterus chilensis) via RNA-seq. Marine Biotechnology, 22(1):94-108. Dettleff, P., Hormazabal, E., Aedo, J., Fuentes, M., Meneses, C., Molina, A., Valdes, J.A.
  • 2019: Evaluating the genetic structure of wild and commercial red cusk-eel (Genypterus chilensis) populations through the development of novel microsatellite markers from a reference transcriptome. Molecular Biology Reports, 46(6):5875-5882. Gonzalez, P., Dettleff, P., Valenzuela, C., Estrada, J.M., Valdés, J.A., Meneses, C., Molina, A.
  • 2019: Influence of Growth differentiation factor 9 (GDF-9) and bone morphogenetic protein 15 (BMP-15) on in vitro maturation of canine oocytes. Reproduction in Domestic Animals, 54(2):373-380. Garcia, P., Aspee, K., Ramirez, G., Dettleff, P., Palomino, J., Peralta, O., Parraguez, V., De los Reyes, M.
  • 2017:  Transcriptomic analysis of spleen infected with infectious salmon anemia virus reveals distinct pattern of viral replication on resistant and susceptible Atlantic salmon (Salmo salar). Fish & Shellfish Immunology, 61:187-193. Dettleff, P., Moen, T., Santi, N., Martinez, V.
  • 2017: Assessment of cathepsin mRNA expression and enzymatic activity during early embryonic development in the yellowtail kingfish Seriola lalandi. Animal Reproduction Science, 180: 23-29. Palomino, J., Herrera, G., Torres-Fuentes, J., Dettleff, P., Patel, A., Martínez, V.
  • 2016: A comprehensive transcriptome of early development in yellowtail kingfish (Seriola lalandi). Molecular Ecology Resources, 16(1):364-76. Patel, A., Dettleff, P., Hernandez, E., Martinez, V.
  • 2015: Patterns of Piscirickettsia salmonis load in susceptible and resistant families of Salmo salar. Fish & Shellfish Immunology, 45: 67-71. Dettleff, P., Bravo, C., Patel, A., Martinez, V.
  • 2014: Growth differentiation factor 9 and bone morphogenetic protein 15 expression in previtellogenic oocytes and during early embryonic development of Yellow-tail Kingfish Seriola lalandi. Biological Research, 47:60. Palomino, J., Herrera, G., Dettleff, P., Martinez, V.
  • 2013: Assessing footprints of selection in commercial Atlantic salmon populations using microsatellite data. Animal Genetics, 44(2):223-6. Martinez, V., Dettleff, P., Lopez, P., Fernandez, G., Jedlicki, A., Yañez, J. M., Davidson, W. S.